South Africa is one of the five countries where the ASCENT project is implemented. Over 50 health care facilities in the Gauteng Province- Tshwane District and Western Cape Province- West Coast District are participating in the project. Patient and health care workers will make use of digital adherence technologies to support patients taking their TB treatment at home. The first patients will be enrolled in October 2020. The project aims to reach 16000 TB patients in South Africa in two years.

South Africa has a population of 58 million people and is one of the 30 high burden TB countries in the world, as listed by the World Health Organization (WHO). According to the WHO in 2018 an estimated 301,000 people suffered from TB in South Africa, making the TB incidence rate 520 per 100,000 people. An estimated 11,000 people suffered from multidrug resistant TB. The WHO estimates 63,000 people died of TB in South Africa in 2018.